Accutane, a popular, but dangerous, acne drug has been pulled from the U.S. market by its manufacturer, Roche Holdings, a Swiss company. Currently, Accutane is the subject of about 700 lawsuits alleging that the drug caused inflammatory bowel disease. Most of the lawsuits have been consolidated in the courts of New Jersey, where the drug is manufactured by Hoffman -LaRoche, a U.S. subsidary of Roche Holdings.
\nInflammatory bowel disease (which is not the same thing as irritable bowel syndrome, or IBS) refers to two diseases that cause inflammation of the intestines, ulcerative colitis and Crohn’s disease. The diseases have some features in common, but there are some important differences.
\nUlcerative colitis is an inflammatory disease of the large intestine, also called the colon. In ulcerative colitis, the inner lining of the intestine becomes inflamed and develops ulcers. Ulcerative colitis is often the most severe in the rectal area, which can cause frequent diarrhea. Mucus and blood often appear in the stool if the lining of the colon is damaged.
\nCrohn’s disease differs from ulcerative colitis in the areas of the bowel it involves. It most commonly affects the last part of the small intestine and parts of the large intestine. However, Crohn’s disease can attack any part of the digestive tract. Crohn’s disease causes inflammation that extends much deeper into the layers of the intestinal wall than ulcerative colitis. Crohn’s disease generally tends to involve the entire bowel wall, whereas ulcerative colitis affects only the lining of the bowel.
\nBy withdrawing the drug from the U.S. market Roche may be hoping to fuel settlements of the pending lawsuits. Roche has lost the six lawsuits that have gone to trial to date with damages totaling more than 33 million dollars.
\nThe lawsuits allege that Roche failed to warn doctors and patients about the risks of developing inflammatory bowel disease.
\nAccutane has previously been linked to birth defects and has been removed from the market in 11 other countries.<\/p>\n